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Approximately half of all novel IPD clones identified in this study were non-conjugate vaccine serotypes. Prevalence of Streptococcus pneumoniae serotypes causing invasive and non-invasive disease in South East Asia: Distribution and invasiveness of Streptococcus pneumoniae serotypes in Switzerland, a country with low antibiotic selection pressure, from to Abstract Streptococcus pneumoniae is a major cause of sepsis, meningitis and respiratory disease worldwide. Serotype incidence among age groups.